EDITORIAL
| Review of 2006 Trevor Laird 1-1 |
| Full: PDF (16 K) |
| Some Items of Interest to Process R&D Chemists and Engineers Mark McLaughlin, Silvina García Rubio, Ulf Tilstam, Octavio Augusto Ceva Antunes, Trevor Laird*, Ganapati D. Yadav, and Andrei Zlota 2-12 |
| Full: PDF (268 K) |
FULL PAPERS
| An Improved Manufacturing Process for Fluvastatin Peter C. Fuenfschilling, Pascale Hoehn, and Jean-Paul Mutz 13-18  |
| Full: PDF (78 K) |
| Development of a Scalable Synthesis of a Common Eastern Tricyclic Lactone for Construction of the Nodulisporic Acids Amos B. Smith, III, László Kürti, Akin H. Davulcu, and Young Shin Cho 19-24  |
| Full: PDF (176 K) |
| Kinetic Data by Nonisothermal Reaction Calorimetry: A Model-Assisted Calorimetric Evaluation Wilfried Hoffmann, Ying Kang, John C. Mitchell, and Martin J. Snowden 25-29  |
| Full: PDF (89 K) |
| Process Development and Scale-up of AG035029 James Saenz, Mark Mitchell, Sami Bahmanyar, Nebojsa Stankovic, Michael Perry, Bridgette Craig-Woods, Billie Kline, Shu Yu, and Kim Albizati 30-38  |
| Full: PDF (322 K) |
| Reductive Carbonylation - an Efficient and Practical Catalytic Route for the Conversion of Aryl Halides to Aldehydes Laura Ashfield and Christopher F. J. Barnard 39-43  |
| Full: PDF (164 K) |
| An Epoxidation Approach to a Chiral Lactone: Application of the Shi Epoxidation David J. Ager, Ken Anderson, Eric Oblinger, Yian Shi, and James VanderRoest 44-51  |
| Full: PDF (100 K) |
| Improved Process for Chloroxidation of Aryl Sulfides to Aryl Sulfonyl Chlorides in Commercial Grade Formic Acid Chen Wang, Christopher Hamilton, Phillip Meister, and Catherine Menning 52-55  |
| Full: PDF (60 K) |
| On the Synthesis of 1,1-Diamino-2,2-dinitroethene (FOX-7) by Nitration of 4,6-Dihydroxy-2-methylpyrimidine Nikolaj V. Latypov, Martin Johansson, Erik Holmgren, Ekaterina V. Sizova, Vladimir V. Sizov, and Anthony J. Bellamy 56-59  |
| Full: PDF (57 K) |
| Efficient Synthesis of (S)-2-(Cyclopentyloxycarbonyl)-amino-8-nonenoic Acid: Key Building Block for BILN 2061, an HCV NS3 Protease Inhibitor Xiao-jun Wang, Li Zhang, Lana L. Smith-Keenan, Ioannis N. Houpis, and Vittorio Farina 60-63  |
| Full: PDF (61 K) |
REVIEWS
| Polymorphisms and Patent, Market, and Legal Battles: Cefdinir Case Study Walter Cabri, Paolo Ghetti, Giovanni Pozzi, and Marco Alpegiani 64-72  |
| Full: PDF (142 K) |
| N,N-Diethyl-(R)-[3-(2-aminopropyl)-1H-indol-7-yloxy]acetamide: Its Process Chemistry Ranging from Enantiocontrolled Construction of the Chiral Amine Side Chain to Regioselective Functionalization of the Aromatic Starting Materials Masaya Ikunaka, Shiro Kato, Daisuke Sugimori, and Yasuhiro Yamada 73-80  |
| Full: PDF (187 K) |
| An Efficient and Impurity-Free Process for Telmisartan: An Antihypertensive Drug Kikkuru Srirami Reddy, Neti Srinivasan, Chinta Raveendra Reddy, Naveenkumar Kolla, Yerremilli Anjaneyulu, Sundaram Venkatraman, Apurba Bhattacharya, and Vijayavitthal T. Mathad 81-85  |
| Full: PDF (101 K) |
TECHNICAL NOTES
| One-Pot Synthesis of 5-Methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one Ramanaiah C. Kanamarlapudi, Mark Bednarz, Wenxue Wu, and Philip Keyes 86-89  |
| Full: PDF (69 K) |
| An Efficient Synthesis of (R)-2-Butyl-3-hydroxypropionic Acid Bin Hu, Mahavir Prashad, Denis Har, Kapa Prasad, Oljan Repic, and Thomas J. Blacklock 90-93  |
| Full: PDF (54 K) |
| Highly Flexible Fibre-Optic ATR-IR Probe for Inline Reaction Monitoring Clemens B. Minnich, Pascal Buskens, H. Christian Steffens, Patrick S. Bäuerlein, Leonid N. Butvina, Lukas Küpper, Walter Leitner, Marcel A. Liauw, and Lasse Greiner 94-97  |
| Full: PDF (236 K) |
| Application of Band-Target Entropy Minimization to On-Line Raman Monitoring of an Organic Synthesis. An Example of New Technology for Process Analytical Technology Effendi Widjaja, Ying Yan Tan, and Marc Garland 98-103  |
| Full: PDF (129 K) |
| SPECIAL FEATURE SECTION: SOLVENTS AND SOLVENT EFFECTS David Lathbury 104-104 |
| Full: PDF (8 K) |
REVIEWS
| Solvents and Solvent Effects: An Introduction Christian Reichardt 105-113  |
| Full: PDF (334 K) |
| Reaction Solvent Selection: The Potential of Water as a Solvent for Organic Transformations Helen C. Hailes 114-120  |
| Full: PDF (95 K) |
| The Potential of Carbon Dioxide in Synthetic Organic Chemistry Christopher M. Rayner 121-132  |
| Full: PDF (223 K) |
| Perspective on Solvent Use in the Pharmaceutical Industry David J. C. Constable, Conchita Jimenez-Gonzalez, and Richard K. Henderson 133-137  |
| Full: PDF (46 K) |
FULL PAPERS
| Polymorphic Generation through Solvent Selection: Ranitidine Hydrochloride Milana Trifkovic, Sohrab Rohani, and Mahmoud Mirmehrabi 138-143  |
| Full: PDF (158 K) |
| Continuous-Flow Suzuki-Miyaura Reaction in Supercritical Carbon Dioxide Gary A. Leeke, Regina C. D. Santos, Bushra Al-Duri, Jonathan P. K. Seville, Catherine J. Smith, Connie K. Y. Lee, Andrew B. Holmes, and Ian F. McConvey 144-148  |
| Full: PDF (94 K) |
| Alternative Solvents: Shades of Green James H. Clark and Stewart J. Tavener 149-155  |
| Full: PDF (257 K) |
| Solvent Applications of 2-Methyltetrahydrofuran in Organometallic and Biphasic Reactions David F. Aycock 156-159  |
| Full: PDF (35 K) |
TECHNICAL NOTES
| Removal of Reaction Solvent by Extractive Workup: Survey of Water and Solvent Co-extraction in Various Systems Laurent Delhaye, Attilio Ceccato, Pierre Jacobs, Cindy Köttgen, and Alain Merschaert 160-164  |
| Full: PDF (371 K) |